Liquid notes 1.5.3.4
Although considering the abundant research results on pillararenes, there have been few reviews on the synthesis of planar chiral or chiral pillararenes, as well as summarizing from the perspective of separation science. Compared to the traditional macrocyclic molecule, these interesting frame structures have drawn a lot of attention in analytical chemistry and separation science in recent years, due to their unique superiority advantages such as pillar-shaped frame, electron-rich cavity and easy to functionalize. In this review, we highlight recent significant advancements for the systematic investigation of achiral, planar chiral and chiral configurations of pillararenes. This work demonstrates an promising future of pillararenes as a new type of stationary phase in chromatographic separations. Moreover, the MP5 column showed good thermal stability and repeatability and reproducibility with the relative standard deviation in the range of 0.02-0.04% for intra-day, 0.32-0.46% for inter-day and 1.5-3.4% for between-column, respectively.
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Particularly, the MP5 stationary phase displays unique retention for dibromoalkanes, which was found to be closely related with the linker length, and shows high resolving capability for a wide range of positional and structural isomers, including alkylbenzenes, chlorobenzenes and chloronitrobenzenes, naphthalene derivatives, phenols and anilines.
![liquid notes 1.5.3.4 liquid notes 1.5.3.4](https://cdn.nettimoto.com/live/2395892/Yamaha-SR-Viper-c401365681993011-large.jpg)
![liquid notes 1.5.3.4 liquid notes 1.5.3.4](https://www.quadratec.com/sites/default/files/styles/product_zoomed/public/product_images/55213.jpg)
The MP5 capillary column fabricated by the sol-gel coating method exhibited weak polarity and high column efficiency over 4200 plates/m for n-dodecane, n-octanol and naphthalene. This work presents the investigation of permethyl pillararene (MP5) as stationary phase for capillary gas chromatographic (GC) separations.